Bioactive Small Molecules
Medchemexpress LLC 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) | 26853-31-6 | 99.9% | 100 MG
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) is a phospholipid and a major component of biological membranes. It is used for the preparation of liposomes and studying the properties of lipid bilayers.
- Phospholipid
- Major component of biological membranes
- Used for liposome preparation
- Used for studying lipid bilayers
- Contains 16:0 and 18:1 fatty acids at sn-1 and sn-2 positions
- White to off-white solid appearance
- Structure classification: Lipid
- Initial source: Plants, Microorganisms, widespread
Medchemexpress LLC BI-3802 | 2166387-65-9 | 99.3% | 484.98 | 1 MG
BI-3802 is a chemical probe and a highly potent BCL6 degrader. It inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. This compound induces the polymerization of BCL6 and promotes BCL6 degradation, which is dependent on the E3 ligase SIAH1. BI-3802 exhibits antitumor activity. It was designed by Boehringer Ingelheim and can be obtained free of charge through their open innovation portal opnMe.com, along with its negative control.
- Highly potent BCL6 degrader.
- Inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM.
- Induces polymerization of BCL6.
- Promotes BCL6 degradation dependent on E3 ligase SIAH1.
- Demonstrates antitumor activity.
- Available as a chemical probe.
Medchemexpress LLC GNE-781 | 1936422-33-1 | 98.5% | 525.59 | 10 MM * 1 ML
GNE-781 | 1936422-33-1 | 98.5% | 525.59 | 10 MM * 1 ML
Medchemexpress LLC JNJ-37822681 dihydrochloride | 2108806-02-4 | 98.7% | 445.26 | 100 MG
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.
- Potent and specific D2 receptor antagonist
- Centrally active
- Fast-dissociating
- Moderate binding affinity for D2L receptor (Ki = 158 nM)
- Potential for treating schizophrenia and bipolar disorder
Medchemexpress LLC A6770 | 1331754-16-5 | ≥99.0% | 140.14 | 1 MG
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. It directly inhibits S1P lyase when phosphorylated. A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase and leads to S1PL inhibition. In vivo, A6770 reduces peripheral lymphocyte numbers in rats.
- Increases [3H]dhS1P in a concentration-dependent manner
- Causes S1PL inhibition
- Reduces peripheral lymphocyte numbers in rats
Abcam 4-Thiouridine, RNA synthesis inhibitor, 25MG
MW 260.27 Da, Purity >99%. Ribonucleoside (Uridine ab143255) analog. Antisense agent. RNA synthesis inhibitor. Modifies oligos slated for RNA. Induces p53 and inhibits proliferation. Metabolically labels RNA for stability studies.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Imiquimod (250 mg)
Chemical. CAS: 99011-02-6. Formula: C14H16N4. MW: 240.3. Immune response modulator. Anti-inflammatory. TLR7 agonist. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Antiviral and anti-angiogenic. Approved treatment for external genital warts caused by human papillomavirus infection.
AdipoGen BAY 43-9006 (25 mg)
Chemical. CAS: 284461-73-0. Formula: C21H16ClF3N4O3. MW: 464.8. Antitumor compound. Broad-spectrum kinase inhibitor. Raf kinase inhibitor. Apoptosis inducer. Cytostatic. Angiogenesis inhibitor. Review.
AdipoGen NG 012 (1 mg)
Chemical. CAS: 141731-76-2. Formula: C32H38O15. MW: 662.7. Isolated from Penicillium sp. FKI-5387. Antibiotic. Antifungal. Nerve growth factor (NGF) potentiator.
AdipoGen Rugulosin (1 mg)
Chemical. CAS: 23537-16-8. Formula: C30H22O10. MW: 542.5. Isolated from Penicillium sp. Antibiotic. Antibacteriophage. Antiviral. Mycotoxin. DNA replication, transcription and repair inhibitor. Antibacterial. RNA polymerase and ribonuclease H inhibitor. Insecticidal. Cytotoxic. HIV-1 integrase inhibitor. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. Potential Hsp90 inhibitor through interacting with N-Hsp90.
AdipoGen Tripolin B (1 mg)
Chemical. CAS: 372164-71-1. Formula: C12H9N3O. MW: 211.2. Aurora A and B modulator.
AdipoGen Ganglioside GQ1b . tetrasodium salt (100 µg)
Chemical. CAS: 68652-37-9. Formula: C106H178N6O55 . 4Na. MW: 2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GQ1b specifically promotes neural differentiation of human neuroblastoma cells. Anti-GQ1b antibodies are present in serum from Miller-Fisher syndrome patients.
AdipoGen Ilimaquinone (100 µg)
Chemical. CAS: 71678-03-0. Formula: C22H30O4. MW: 358.5. Isolated from Anthelia sp. Cytoplasmic microtubule inhibitor. Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures. Blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane. Blocks protein transport to the plasma membrane and inhibits gap junctional communication. HIV-1 inhibitor. Blocks the cytotoxicity of ricin and diphtheria toxin. S-Adenosylhomocysteinase hydrolase inhibitor and cellular methylations inhibitor. DNA polymerase beta lyase activity inhibitor. Anti-cancer compound.
AdipoGen Chelerythrine chloride (25 mg)
Chemical. CAS: 3895-92-9. Formula: C21H18ClNO4. MW: 383.8. Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor.
AdipoGen Curcumin (high purity) (250 mg)
Chemical. CAS: 458-37-7. Formula: C21H20O6. MW: 368.4. Synthetic. Originally isolated from turmeric (Curcuma longa). Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog (Shh) signaling pathway modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS; NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator.